A safety study of inactivated Enterovirus 71 vaccine
نویسندگان
چکیده
منابع مشابه
Preclinical Evaluation of the Immunogenicity and Safety of an Inactivated Enterovirus 71 Candidate Vaccine
Human enterovirus 71 (EV71) is a significant cause of morbidity and mortality from Hand, Foot and Mouth Disease (HFMD) and neurological complications, particularly in young children in the Asia-Pacific region. There are no vaccines or antiviral therapies currently available for prevention or treatment of HFMD caused by EV71. Therefore, the development of therapeutic and preventive strategies ag...
متن کاملLong-Term Immunogenicity Studies of Formalin-Inactivated Enterovirus 71 Whole-Virion Vaccine in Macaques
Enterovirus 71 (EV71) has caused epidemics of hand, foot and mouth diseases in Asia during the past decades and no vaccine is available. A formalin-inactivated EV71 candidate vaccine (EV71vac) based on B4 subgenotype has previously been developed and found to elicit strong neutralizing antibody responses in mice and humans. In this study, we evaluated the long-term immunogenicity and safety of ...
متن کاملImmunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations
BACKGROUND To investigate the long-term effects on immunity of an inactivated enterovirus 71 (EV71) vaccine and its protective efficacy. METHODS A sub-cohort of 1,100 volunteers from Guangxi Province in China was eligible for enrolment and randomly administered either the EV71 vaccine or a placebo on days 0 and 28 in a phase III clinical trial and then observed for the following 2 years with ...
متن کاملForecasting the economic value of an Enterovirus 71 (EV71) vaccine.
Enterovirus 71 (EV71) is a growing public health concern, especially in Asia. A surge of EV71 cases in 2008 prompted authorities in China to go on national alert. While there is currently no treatment for EV71 infections, vaccines are under development. We developed a computer simulation model to determine the potential economic value of an EV71 vaccine for children (<5 years old) in China. Our...
متن کاملAppendix B. —Safety and Efficacy of Inactivated Influenza Vaccine Description of Inactivated Influenza Virus Vaccine
Influenza vaccines can be categorized in two basic groups—live, which contain small amounts of live, attenuated (weakened) influenza viruses, and inactivated, which contain either whole influenza viruses or subunits of viruses. Only inactivated influenza viruses are licensed for general use in the United States; therefore, this discussion of vaccine safety and efficacy pertains exclusively to i...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2013
ISSN: 2164-5515,2164-554X
DOI: 10.4161/hv.24395